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HMGCS2 Rabbit mAb [x0pU]Cat NO.: A22318

Western blot(SDS PAGE) analysis of extracts from Caco-2 cell lysate.Using HMGCS2 Rabbit mAb [x0pU]at dilution of 1:1000 incubated at 4℃ over night.

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订单 Datasheet

Product information

Protein names :HMG CoA synthase; HMGCS2;

UniProtID :P54868

MASS(da) :56,635

MW(kDa) :50kDa

Form :Liquid

Purification :Affinity-chromatography

Host :Rabbit

Isotype : IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • 免疫组化(IHC)1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with A synthesized peptide derived from human HMGCS2

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :Caco-2 cell lysate.

Function : Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate..

Tissue specificity :Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825)..,[Isoform 3]: Highest expression detected in heart and skeletal muscle..

Subcellular locationi :Mitochondrion.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.