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ARTS1/ERAP1 Rabbit mAb [AB68]Cat NO.: A93242

Western blot(SDS PAGE) analysis of extracts from K562 cells.Using ARTS1/ERAP1Rabbit mAb [AB68] at dilution of 1:1000 incubated at 4℃ over night.

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订单 Datasheet

Product information

Protein names :ERAP1,APPILS,ARTS1,KIAA0525,UNQ584/PRO1154,ERAP1_HUMAN,Endoplasmic reticulum aminopeptidase 1

UniProtID :Q9NZ08

MASS(da) :107,235

MW(kDa) :107 kDa

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • 免疫组化(IHC)1:100
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of human ARTS1/ERAP1

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :K562 cells

Function : Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney..

Tissue specificity :Ubiquitous.

Subcellular locationi :Endoplasmic reticulum membrane,Single-pass type II membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.