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Phospho-IP3 Receptor (Ser1756) Rabbit mAb[39HW]Cat NO.: A79921

Western blot(SDS PAGE) analysis of extracts from mouse brain..Using Phospho-IP3 Receptor (Ser1756)Rabbit mAb IgG [39HW] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :ITPR1,INSP3R1,ITPR1_HUMAN,Inositol 1,4,5-trisphosphate receptor type 1

UniProtID :Q14643

MASS(da) :313,929

MW(kDa) : 320

Form :Liquid

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity :Human,Mouse,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1756 of human IP3 Receptor

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected :mouse brain.

Function : Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)..

Tissue specificity :Widely expressed..

Subcellular locationi :Endoplasmic reticulum membrane,Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane,Multi-pass membrane protein. Cytoplasm, perinuclear region.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.