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Western blot(SDS PAGE) analysis of extracts from fetal human brain tissue.Using CISD2-Specific Mouse mAb IgG [1E3Y] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :CISD2,CDGSH2,ERIS,ZCD2,CISD2_HUMAN,CDGSH iron-sulfur domain-containing protein 2
UniProtID :Q8N5K1
MASS(da) :15,278
MW(kDa) :15kDa
Form :Liquid
Purification :Protein A purification
Host :Mouse
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human CISD2-Specific.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :fetal human brain tissue
Function : Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy..
Tissue specificity :Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets..
Subcellular locationi :Endoplasmic reticulum membrane,Single-pass membrane protein. Mitochondrion outer membrane,Single-pass membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.