DR5 Rabbit mAb [XL95]Cat NO.: A77546

Protein names ：TNFRSF10B,DR5,KILLER,TRAILR2,TRICK2,ZTNFR9,UNQ160/PRO186,TR10B_HUMAN,Tumor necrosis factor receptor superfamily member 10B

UniProtID ：O14763

MASS(da) ：47,878

MW(kDa) ：40, 48 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human DR5

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HCT116 cells

Function ： Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis..

Tissue specificity ：Widely expressed in adult and fetal tissues,very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361,highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract,not detectable in brain.

Subcellular locationi ：Membrane,Single-pass type I membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.