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Western blot(SDS PAGE) analysis of extracts from Neuro-2a cells.Using PHOX2B Mouse mAb IgG [1108] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :PHOX2B,PMX2B,PHX2B_HUMAN,Paired mesoderm homeobox protein 2B
UniProtID :Q99453
MASS(da) :31,621
MW(kDa) :32kda
Form :Liquid
Purification :Protein A purification
Host :Mouse
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of human PHOX2B.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Neuro-2a cells
Function : Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
Tissue specificity :Expressed in neuroblastoma, brain and adrenal gland.
Subcellular locationi :Nucleus.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.