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Western blot analysis of extracts from Human fetal brain tissue lyaste.using CAPON/NOS1AP Rabbit mAb [7J0W] at dilution of 1:1000 incubated at 4℃ over night
Protein names :NOS1AP,CAPON,KIAA0464,CAPON_HUMAN,Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
UniProtID :O75052
MASS(da) :56,150
MW(kDa) :56 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human,Mouse,Rat
Specificity :Antibody is produced by immunizing animals with a synthetic peptide of Human CAPON/NOS1AP.
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected :Human fetal brain tissue lyaste
Function : Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)..
Tissue specificity :Expressed in kidney glomeruli podocytes..
Subcellular locationi :Cell projection, filopodium. Cell projection, podosome.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.